Since nothing is known about the effects of third-hand smoke on wound healing, it seems very appropriate that this research team is going to investigate this research question using a mouse model to find out whether there are adverse effects of thirdhand smoke.

Fortunately, there is a simple way to evaluate this hypothesis, at least on a preliminary basis, prior to waiting for the results of longitudinal studies. Enough youth are experimenting with electronic cigarettes, and the increase in youth e-cigarette use has been dramatic and sustained enough, that if the gateway hypothesis were correct, we would be starting to see an increase in smoking prevalence among youth due to the many new smoking initiates that were converted from e-cigarette experimentation to smoking.

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