By publicly refuting the black box warning, Pfizer is literally spitting in the face of the FDA. This is not appropriate. The company should either be penalized and forced to discontinue its campaign of refutation of the black box warning findings, or the drug should be pulled from the market due to a finding that the company has violated the terms of the drug's approval.

Even if e-cigarette vapor shows some toxicity in cell culture studies, how does that demonstrate that vaping is more harmful than smoking?

What would be an example of such a severe problem that it warrants reporting to the FDA? to the medical branch chief in the Office of Science at FDA's Center for Tobacco Products, such a severe problem would be something like if a cigarette "just smells or tastes wrong."

Another thing to consider is the bottles being used to store the E-Juice. Now I know this may sound silly as different types of bottles driving up the price and quality of E-Juice but it can. For instance, glass bottles are generally five to ten times more expensive then plastic dropper bottles even purchased in bulk. Most premium E-Juice manufacturers refuse to use plastic bottles because they claim it can distort the taste overtime as certain flavors and plastic do not play well together. Although the flavorings are delivered to the manufacturers in plastic bottles, so I want to say this is more tongue in cheek than anything else. But there are some benefits aside from pure ascetics with a glass bottle. A glass bottle makes steeping and curing a lot easier than a plastic bottle. A lot of the times when E-Juice comes in the mail, it needs a few days to a week of steeping/curing for the flavors and base to be homogenous. To speed this process up a lot of veterans give the E-Juice bottles an 8 to 12 hour “warm bath” via a slow cooker. This method speeds the steeping process from a week to a few hours. Having glass bottles are generally favorable as the plastic bottles tend to float. Obviously glass bottles are more prone to damage than plastic bottles not to mention getting E-Juice into a tank without some sort of squeeze bottle can be a daunting task as well.

The odds ratio for successful quitting for the e-cigarette group compared to subjects who used no cessation aid was 1.38 (95% confidence interval, 1.08-2.93).

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