The problem is that in this cross-sectional study, there is no way to determine the direction of the observed relationship.

Trueba et al. also found that higher depressive mood was associated with greater reductions in exhaled nitric oxide.

2. Between 2010 and 2012, the other co-author conducted studies using a variety of smokeless tobacco products. While the studies were not funded by a tobacco company, the study products were provided free of charge by U.S. Tobacco. Previously, this co-author did conduct tobacco industry-funded studies, which he acknowledged in a 2008 publication. This funding apparently goes all the way back to at least 2000. In addition, the researcher used to do consulting work for Star Scientific, U.S. Tobacco, Liggett, and Santa Fe Natural Tobacco Company, although none of that consulting occurred within the past three years.

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