The letter concludes: "I really hope you will reconsider your approach – it does not serve public health or the public interest. It is wrong simply to assume that e-cigarettes will play no part in reducing the expected one billion 21st Century deaths from smoking. The evidence that there is, taken as a whole, is actually very encouraging, and certainly not a reason to mount a ‘dirty tricks campaign’ against these products. In any event, there is never a case to mislead the public, policy-makers and legislators even if you are convinced the end justifies the means, which in this case it does not."

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What the study did show was subclinical evidence of impaired lung function, meaning that the observed (measurable) lung function was unchanged, but that there was evidence of physiologic effects consistent with some bronchial inflammation. What is not known is whether this acute bronchial inflammation has any significance in the long-term. The presence of bronchial inflammation may be a result of propylene glycol having a respiratory irritant effect. But this does not necessarily mean that long-term exposure would lead to any adverse effect on lung function. More research is necessary to clarify that point.

In my view, there is only one possible explanation for this: Dr. Glantz is no longer playing by the rules of science. He is now a man on a mission: to destroy the e-cigarette industry and to remove e-cigarettes as an option for smokers trying to quit. He has apparently drawn the pre-determined conclusion that e-cigarettes are aggravating the tobacco epidemic among youth, and he will stop at nothing to draw this conclusion and disseminate it to the public.

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