At the time the experiment was initiated in 1932, the treatment for syphilis involved toxic drugs. However, by the 1940's, penicillin was readily available as a treatment for this infection. Nevertheless, the study continued and penicillin was not made available to these black men. Nor were they informed about the availability of the medicine or even of what disease they actually had.

Prior to this study, the most significant health concern regarding passive vaping was the possibility of exposure to carcinogenic and toxic aldehydes and pyrolysis products including formaldehyde, acrolein, and acetone. However, this study found no increase in concentrations of any of these pollutants under realistic (real-life) conditions.

If this study leads some smokers to smoke inside because they believe the researchers, who say that thirdhand smoke is no less harmful than secondhand smoke, then this could lead to serious public health harm to children.

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