Some of the researchers and advocates who opposed our crowdfunding campaign to raise money for a randomized behavioral study of the effects of electronic cigarettes on smoking behavior argued that randomized clinical trials (RCTs) are simply not appropriate to study e-cigarettes because they cannot simulate the real-life situation, where smokers have many choices of different types of products, can engage with social networks, and can experiment over time, change products, advance from one type of product to another, etc.

A final, important benefit of smoking reduction is that it helps facilitate the possibility that a smoker will subsequently be able to quit. It reduces the level of smoking addiction. It is easier to quit from a level of 5 cigarettes per day than it is to quit from a level of 30 cigarettes per day.

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The black box warning, then, advises physicians to observe patients being put on Chantix for "suicide-related events," including "suicide."

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