A third major advantage of a clinical trial is that conditions are controlled as carefully as possible, minimizing potential biases. Both sampling and measurement bias are greatly reduced, if not eliminated. In contrast, survey studies are generally subject to significant sampling and measurement bias.

In other words, there appears to be strong evidence that in the UK, electronic cigarette use is not serving as a gateway by which nonsmokers are becoming addicted to nicotine and then progressing to real cigarette smoking.

One of the first things you need to decide is if you like a sweeter taste, or a real tobacco taste. At first, many smokers prefer an e-juice with a tobacco taste, but many will gradually shift into sweeter flavors like apple or strawberry.

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