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The randomized study provides a number of important benefits that can never be realized in a survey study. Most importantly, the RCT can equalize between study groups the known and unknown confounding variables that may lead to invalid study results.

By Stan's logic, we should throw out all the clinical trials upon which the established effectiveness of NRT is based because every one of these trials was designed to assess the efficacy of NRT among smokers who used these drugs with the specific intent to quit. Instead, according to Glantz's logic, we should examine the rate of smoking cessation among everyone who has ever used an NRT product. Doing that would lead to the conclusion that NRT is completely ineffective for smoking cessation.

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