Well, Polosa et al. have conducted exactly such a . They examined the changes in asthma symptoms among smokers who continue to smoke versus those who switch to electronic cigarettes. These investigators reported that in contrast to real cigarettes, the fake ones result in actual harm reversal. Lung function, asthma control, and asthma symptoms were significantly improved among patients who switched from regular cigarettes to electronic cigarettes. These improvements were even observed among patients who became dual users of both real and fake cigarettes.

After one year follow-up, both the ex-smokers and dual users experienced a significant improvement in asthma symptoms and lung function, especially small airways obstruction. Although the improvements in lung function were small, the improvements in asthma symptoms were clinically relevant.

"It is not known how much nicotine or other potentially harmful chemicals are inhaled by users, nor is it known whether e-cigarette use may lead to use of other tobacco products. Neither are the benefits of using e-cigarettes over traditional products known."

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