Because products are substantially equivalent only if they pose no different issues of public health, and because flavorings can affect product efficacy and safety, it is probable that every different flavor of every different brand must submit a separate application. Thus, at a minimum, there are going to be at least 466 x 49 applications, or 22,834 required applications.

What does it mean to be "opposed" to the use of unregulated e-cigarettes? It means that the European Respiratory Society is opposed to the use of e-cigarettes in any setting in which they are unregulated, such as the current situation throughout most of the world, including in the United States.

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