One thing that is true is that there are no cardiovascular benefits to smoking reduction. The reason for this is that the adverse cardiovascular effects of smoking saturate at a low level of exposure. However, with carcinogenic effects as well as lung disease, there is a well-recognized dose-response relationship between exposure and disease risk. Therefore, substantial smoking reduction has no cardiovascular benefit but it does lower lung cancer risk and respiratory morbidity.

Surprisingly, however, the next paragraph of the grant application abstract informs grant reviewers that the researchers actually know the results of this experiment before conducting it. The researchers tell the reviewers that:

For obvious reasons, the Glantz approach is the wrong one to take, and the Brown et al. approach is correct. This study demonstrates that when you analyze the data the proper way, it appears that electronic cigarettes -- for the right smokers -- can be an effective smoking cessation tool.

In fact, it appears that many anti-smoking advocates and groups do not actually want smokers to quit using e-cigarettes. They would rather smokers continue to smoke than to use a device which looks like a cigarette but is actually much safer. After all, for most smokers who quit using e-cigarettes, advice telling them not to use the e-cigarette is tantamount to instructing them to return to cigarette smoking. The chances that such smokers will succeed with FDA-approved methods is near nil. In fact, the very reason that most of them have tried e-cigarettes in the first place is because they had tried FDA-approved methods in the past and failed or they had little confidence that such methods would work.

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