For example, I am proud of having been part of a team that was the first ever to report that the dietary supplement L-tryptophan can via the eosinophilia-myalgia syndrome. This important conclusion - which had major public health policy implications - was based on a single reported case of pulmonary hypertension. In other words, it was based on a single "anecdote." Had we dismissed this finding because a single anecdote is not data, then we would have failed to report this relationship and many more patients would have suffered that fate, possibly leading to fatalities.

Instead of whining about the tobacco companies evading the FDA tobacco law by using colors to denote the brands formerly known as "lights" or "milds," the Campaign for Tobacco-Free Kids and the other major anti-smoking groups should be apologizing to its constituents and to the public for knowingly crafting legislation that would not accomplish its declared purpose.

These data all but destroy the gateway hypothesis. They demonstrate that at the current time, the evidence simply does not support the assertion that the proliferation of e-cigarette use among youth is leading to increased smoking initiation. Electronic cigarettes are not leading to a lifetime addiction to cigarette smoking among our nation's youth.

First, in contrast to what Stan Glantz is arguing, dual use does not appear to be an "adverse consequence" of e-cigarette experimentation. Instead, it appears to be a positive effect that results in a substantial reduction in cigarette consumption among smokers who would almost certainly not have quit smoking altogether in the absence of electronic cigarettes.

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